According to relevant medical statistics, the incidence of gastric cancer ranks fourth among malignant tumors in the world, and gastric cancer ranks second among the causes of death from malignant tumors. Nearly 40% of gastric cancers in the world are located in China. The diagnosis and treatment rate of early gastric cancer in China is 10%, far lower than 70% in Japan and 50% in South Korea. Modern medicine has shown that most early gastric cancers can be cured by endoscopy, and the 5-year survival rate after surgery is over 90%.
(1) There are people over the age of 40 (regardless of gender).
(2) People in areas with high incidence of gastric cancer.
(3) Helicobacter pylori infection.
(4) High-risk groups with precancerous diseases (such as atrophic gastritis, gastric ulcer, gastric polyps, post-operative remnant stomach, hypertrophic gastritis, pernicious anemia, etc.) have been identified in the past gastric examination.
(5) First-degree relatives of gastric cancer patients (parents, children, and siblings with the same parents).
(6) People with other high-risk factors for gastric cancer (high-salt diet, preserved food, smoking, heavy drinking, etc.).
More than 70% of patients with early gastric cancer may be asymptomatic, and some patients may only present with upper abdominal discomfort or pain, and symptoms often aggravate after eating. As the disease progresses, the pain intensifies, with frequent attacks, accompanied by decreased appetite, fatigue, nausea and vomiting, belching, pantothenic acid, and heartburn. There are many methods for early diagnosis and detection of gastric cancer, and gastric function test is currently the preferred screening method for early detection, early diagnosis and early treatment in gastric cancer prevention.
Gastric function test is a non-invasive, simple, rapid, and cost-effective method for early gastric cancer screening. The four items of gastric function detection include: pepsinogen I (PG I), pepsinogen II (PG II), pyloric helix antibody, and gastrin-17.
(1) PGⅠ is mainly secreted by chief cells and cervical mucous cells of fundic glands located in the fundus and body of the stomach.
(2) PG II, secreted by fundic glands, gastric antral pyloric glands and proximal duodenal glands.
(3) PG, a good indicator of gastric corpus mucosal acid secretion function, is called "serological biopsy". Through the difference of its serum measurement value, there are different degrees of changes in each gastric disease, which provides a reliable diagnostic value for the clinic.
(4) Detection of Helicobacter pylori antibody to reflect whether there is Helicobacter pylori infection.
(5) Gastrin-17 is a gastrointestinal hormone mainly secreted by gastric antrum and duodenal G cells, which plays an important role in regulating the function of the digestive tract and maintaining its structural integrity.
